search
for
 About Bioline  All Journals  Testimonials  Membership  News  Donations


African Journal of Biomedical Research
Ibadan Biomedical Communications Group
ISSN: 1119-5096
Vol. 19, No. 3, 2016, pp. 235-239
Bioline Code: md16033
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Biomedical Research, Vol. 19, No. 3, 2016, pp. 235-239

 en Antiulcer Effects of Melatonin in Wistar Rats –The Roles of Gastric Mucous, Antioxidants and Zinc
Oluwole, F.S.; Ajieh, C.E. & Ayoade, J.T.

Abstract

Melatonin is known as a potent scavenger of reactive oxygen species. Zinc has also been reported to be involved in tissue regeneration. This activity has been suggested partly as its gastroprotective mechanism. The digestive system has been estimated to produce about 400 times of this neurohormone than the pineal gland. In this study, we report the role of gastric anti-oxidant enzymes, luminal mucosa zinc level and gastric mucus cell counts in the anti- ulcer effects of melatonin in rats. The experimental Wistar rats were divided into five (5) study groups. Each group was further divided into 5 subgroups (n=5) viz: /l Control, Melatonin (20 and 40mg/kg) pre-treated, Ranitidine pre-treated and Omeprazole pre-treated. Drugs were administered orally for 21 days. The effect of melatonin was investigated on indomethacin-induced gastric ulcer and gastric mucus cell counts in rats were measured. The luminal mucosa zinc levels, gastric antioxidant enzymes (SOD and Catalase), and oxidative biomarker for lipid peroxidation; Malondialdehyde (MDA) were determined. Our results showed suppression of oxidative stress (ROS) or its inhibition after 21 days of melatonin pre-treatment in rats. Catalase exhibited significantly stronger activity better than superoxide dismutase. Our study also shows enhanced gastric mucus cell counts in the pre-treated rats. The anti-ulcer mechanisms of melatonin may be due to stimulation of gastric mucus production via raised mucus cell counts, in addition to melatonin reactive oxygen species scavenging ability. It is however, not associated with changes in luminal mucosa zinc level.

Keywords
Melatonin; gastroprotection; antioxidant; indomethacin; zinc

 
© Copyright 2016 - African Journal of Biomedical Research

Home Faq Resources Email Bioline
© Bioline International, 1989 - 2019, Site last up-dated on 18-Mar-2019.
Site created and maintained by the Reference Center on Environmental Information, CRIA, Brazil
System hosted by the Internet Data Center of Rede Nacional de Ensino e Pesquisa, RNP, Brazil