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African Journal of Biomedical Research
Ibadan Biomedical Communications Group
ISSN: 1119-5096
Vol. 20, No. 1, 2017, pp. 99-102
Bioline Code: md17013
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Biomedical Research, Vol. 20, No. 1, 2017, pp. 99-102

 en Effect of Methanolic Extract of Hibiscus sabdariffa check for this species in other resources in Ethanol-Induced Hepatotoxicity
Olanrewaju, E; Anyaehie, B; Ezeh, C.O; Onyekwelu, K.C & Ezeh, R.C

Abstract

The liver is one of the most important organs in the body which aids in the maintenance of normal body functions. It is the center of alcohol metabolism and alcohol has been implicated in the elevation of liver enzymes and damage to the parenchyma cells of the liver. Plants had been used for medicinal purposes long before recorded history and many people worldwide rely on herbal medicines for some part of their primary health care. The objective of this study was to evaluate the activity of Hibiscus sabdariffa on the liver of rats following repeated administration of ethanol. Hepatotoxicity was induced on the rats using ethanol and the levels of serum enzymes such as serum glutamic pyruvic transaminase (SGPT), serum glutamic oxaloacetic transaminase (SGOT), total and conjugated bilirubin were estimated. The levels of hepatic enzymes ( SGOT, SGPT and bilirubin) in the serum were significantly increased (P < 0.05) in rats treated with ethanol when compared with the control ( Pre phase). In the post phase, administration of different doses of ethanol extract significantly reduced the levels of increased hepatic serum enzymes when compared with the control. Methanolic extract of Hibiscus sabdariffa seems to have hepatoprotective effect on ethanol induced liver damage. However, similar study needs to be carried out on human to prove the authenticity of hepatoprotective effect of Hibiscus sabdariffa.

Keywords
Hibiscus sabdariffa; hepatoprotective; SGOT; SGPT; bilirubin.

 
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