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African Journal of Biomedical Research
Ibadan Biomedical Communications Group
ISSN: 1119-5096
Vol. 20, No. 2, 2017, pp. 137-144
Bioline Code: md17019
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Biomedical Research, Vol. 20, No. 2, 2017, pp. 137-144

 en Red Palm Oil Supplementation Ameliorates Oxidative Stress in Rats Injected with Tert-Butylhydroperoxide
Alinde, OBL; Rooyen, J V & Oguntibeju, O.O


Potential benefits of dietary supplementation as quenching agent against oxidative stress-related conditions has been extensively investigated. Red palm oil (RPO), from the tropical plant Elaeis guineensis check for this species in other resources has captivated much interest in the health sector lately; hence the aim to assess the potential effects of RPO supplementation on the antioxidant status and protection against oxidative damage in experimentally-induced oxidative stress male Wistar rats. Male Wistar rats were randomly divided into four groups (n=5). Rats were fed 0.175g RPO (7g RPO/kg chow) supplementation for 6 weeks. Oxidative stress was induced by intraperitoneal injections of 0.5mL (20µM/100g of body weight) organic tert-butylhydroperoxide (t-BHP). All parameters were determined in plasma and erythrocytes by using appropriate methods. Data were expressed as mean ± SEM. Exposure to t-BHP caused a significant increase in malondialdehydes (MDA) levels in plasma of non-supplemented rats. MDA was significantly reduced by RPO-supplementation. This proved that RPO-supplementation reduced the increase in MDA level induced by t-BHP injection, thereby protecting cellular integrity against induced oxidative stress. Superoxide dismutase (SOD) activity increased significantly (p<0.05) in group supplemented with RPO not induced with oxidative stress. This suggests that RPO supplementation could also improve antioxidant status in a biological system. RPO supplementation offers a protective effect against lipid peroxidation in an oxidative stress-induced biological system and that RPO supplementation had potential benefits in improving antioxidant status

Palm oil; oxidative stress; antioxidant; antioxidative status; supplementation

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