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African Journal of Biomedical Research
Ibadan Biomedical Communications Group
ISSN: 1119-5096
Vol. 20, No. 3, 2017, pp. 277-285
Bioline Code: md17042
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Biomedical Research, Vol. 20, No. 3, 2017, pp. 277-285

 en Antinociceptive and Anti-inflammatory properties of a polyherbal extract of Plumbago zeylinica check for this species in other resources and Capsicum frutescens check for this species in other resources in rodents
Alabi, A.; Ajayi, A.M.; Olooto, W.E.; Emegoakor, C.; Oladunjoye, O. & Obikoya, Y.

Abstract

The aim of the present study is to evaluate the anti-nociceptive and anti-inflammatory properties of an extract of a polyherbal mixture containing the leaves and roots of Plumbago zeylinica and fruits of Capsicum frutescens. Acute toxicity effect of WAP was evaluated in mice. The antinociceptive and anti-inflammatory activities of WAP (100–400 mg/kg) were investigated in hot plate, acetic acid-induced writhing, carrageenan-induced paw oedema and air pouch models. No death was recorded when WAP was administered at a dose of 2000 mg/kg. Oral treatment with WAP elicited inhibitory activity in hot plate test. Abdominal writhing was significantly reduced by WAP at 100, 200 and 400 mg/kg (54.5 ± 1.6, 20.0 ± 7.4, 38.4 ± 4.8) as compared with the control group (71.0 ± 2.6). Carrageenan-induced oedema formation was significantly (p < 0.05) reduced at WAP (100, 200, and 400 mg/kg) by 23.5, 27.3 and 31.4%, respectively, and by reference to indomethacin (10 mg/kg, 31.2%). WAP (200 and 400 mg/kg) significantly reduced exudate volume (37.2 and 44.1%), protein (42.0 and 54.1%), total leucocytes (59.1 and 60.2) and neutrophils count (57.3 and 58.0%) in the carrageenan-induced air pouch in rats. Similarly, WAP treated animals showed reduced nitrites and malondialdehyde levels and increased glutathione levels. Furthermore, WAP (400 mg/kg) nether affected locomotory activity nor induced gastric lesion in mice. The results of this study revealed that extract of a polyherbal mixture containing the leaves and roots of Plumbago zeylinica and fruits of Capsicum frutescens possesses anti-noiceptive and anti-inflammatory activity.

Keywords
Polyherbal; Plumbago zeylinica; Capsicum frutescens; inflammation; rats

 
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