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African Journal of Biomedical Research
Ibadan Biomedical Communications Group
ISSN: 1119-5096
Vol. 21, No. 1, 2018, pp. 11-13
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Bioline Code: md18003
Full paper language: English
Document type: Research Article
Document available free of charge
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African Journal of Biomedical Research, Vol. 21, No. 1, 2018, pp. 11-13
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Assessment of Programmed Cell Death Proteins in Oral Squamous Cell Carcinoma
Udeabor, SE; Adisa, AO; Orlowska, A; Sader, RA & Ghanaati, S
Abstract
Oral squamous cell carcinoma (OSCC) is a significant health concern in Nigeria and although the prevalence is relatively low
compared to other populations, late patient presentation, yet to be clearly defined etiology and inadequate facilities for
management result in high mortality rates. Chronic inflammation, which borders on immunological concepts of cancer biology
have been proposed as contributory. Seeing that immunology is a ‘double-edged sword’ that can be manipulated for therapy, it
is needful to explore this model in OSCC found in Nigerian patients. We aim to investigate the expression of and relationship
between PD-1, PD-L1 and PD-L2 in OSCC. This is important because there are now immunotherapies that target the cell
programmed death pathway. Twenty FFPE blocks of OSCC were prepared for immunohistochemistry to Abcam Mouse
monoclonal Anti-PD1 antibody, Rabbit monoclonal Anti-PD-L1 antibody and Rabbit Polyclonal Anti-PD-L2.
Cytoplasmic/membrane staining was taken as positive for the antibodies. The Sinicrope scoring method was used to evaluate
staining intensity and proportion. We found that tumor associated macrophages and neoplastic cells expressed PD1, PD-L1 and
PD-L2 in differing proportions, but most of the cases were negative for these antibodies. Our results have shown that
immunotherapy may be relevant when considering the management of OSCC patients in Nigeria
Keywords
programmed cell death; oral squamous cell carcinoma
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© Copyright 2018 - African Journal of Biomedical Research
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