Design and Evaluation of Oral Dissolving Films of Chlorpheramine From Native and Modified Enterolobium cyclocarpum Gum|
Ayorinde, J.O.; Effiong, D.E. & Odeniyi, M.A
Pharmaceutical excipients of natural origin have numerous advantages which include biocompatibility, non toxicity and
biodegradability. Selection of a suitable film-forming polymer is important in the formulation of oral fast dissolving films. This
work aims to investigate a natural gum from Enterolobium cyclocarpum tree, as a film forming polymer in chlorpheniramine
oral film formulations; comparing it with hydroxylpropylmethyl cellulose (HPMC). Enterolobium gum was modified, using
acetic anhydride (acetylation) and ethylene glycol. Physicochemical properties of native and modified gums were determined.
Oral dissolving films were prepared from blends of HPMC and either native, acetylated or ethylene glycol modified gum, using
the solvent evaporation technique. Films were evaluated for weight variation, thickness, folding endurance, in-vitro disintegration
and release properties. FT-IR revealed no adverse chemical interaction. High moisture content was shown by the swelling index
determination; acetic anhydride modified gum had the highest (p<0.05). The gums were of neutral pH, the modification methods
significantly reduced viscosity of the gum. Native and modified gums produced films of acceptable qualities. Modification by
acetylation produced films with better mechanical properties. Films produced with blends of native gum/HPMC and acetylated
gum/HPMC had better release profile than those produced by HPMC. Drug release from the films improved with increasing
concentration of the gum, up to an optimum gum/HPMC blend ratio of 2:3. Physicochemical properties of Enterolobium gum
improved by gum modification. Enterolbium gum proved to be a suitable polymer in chlorpheniramine oral dissolving films.
Modification by ethylene glycol produced films with best drug release profile.
Oral dissolving films; Enterolobium gum; Chlorpheniramine; Natural polymer