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African Journal of Biomedical Research
Ibadan Biomedical Communications Group
ISSN: 1119-5096
Vol. 21, No. 2, 2018, pp. 211-217
Bioline Code: md18032
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Biomedical Research, Vol. 21, No. 2, 2018, pp. 211-217

 en Resveratrol and Vitamin E ameliorate Carbendazim-induced toxicity in Wistar rats
Ola-Davies, O.E.; Olukole, S.G. & Ozegbe, P.C.

Abstract

Carbendazim [methyl-2-benzimidazole carbamate, MBC (CBZ)], a metabolite of benomyl, is one of the most widespread environmental contaminants of major concern to human and animal health. The protective effect of resveratrol (RSV), vitamin E (E) and a combination of both on carbendazim-induced toxicity was investigated using haematology, serum biochemistry and histopathology in male Wistar rats. Exposure to Carbendazim (CBZ) caused a significant reduction in the values of PCV and significantly increased WBC as well as platelets counts when compared to the control and other groups while treatment with each of and a combination of RSV and E ameliorated the condition. Also, exposure to CBZ resulted in a significant increase in the values of Urea, Creat, AST, ALT, GGT, Total Cholesterol, Triglycerides and Low Density Lipoproteins while it decreased HDL across the groups. However, RSV and or E ameliorated the condition. Histopathology revealed that CBZ exposure resulted in inflammation of the glomerular apparatus as well as focal areas of granulation and hepatic lesions including fatty degeneration, peri-portal inflammation, cytoplasmic vacuolation and karyorrhexis of hepatocytes in the kidney and liver, respectively. Co-treated with E, RSV or their combination improved the conditions in the kidney and liver. The study demonstrates the ameliorating effects of RSV, E as well as their combination on CBZ-induced toxicities

Keywords
Carbendazim, resveratrol; vitamin E; kidney; liver

 
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