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African Journal of Biomedical Research
Ibadan Biomedical Communications Group
ISSN: 1119-5096
Vol. 2, No. 1, 1999, pp. 23-27
Bioline Code: md99005
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Biomedical Research, Vol. 2, No. 1, 1999, pp. 23-27

 en EFFECTS OF DRUGS AND IONIC VARIATIONS ON CONTRACTIONS OF RAT SMOOTH MUSCLES
PETER. I. AZIBA and OKUNOLA M. C.

Abstract

Chemical agents, Acetylcholine, Ach (5.0 x 10-9 - 4.0 x 10-8 Noradrenaline, NA (6.6 x 10-5 - 5.2 x 10-4M) and Potassium, K+ (25mM, 50mM) which stimulate different receptor populations in smooth muscle contractions and their ionic channel properties have been examined in different isolated preparations of Rat Ileum (RI), Rat Stomach Strip (RSS), and Rat Vas Deferens (RVD) using known Ca2+ channel and specific receptor blockers. Atropine and Phentolamine respectively blocked Ach and NA competitively. While effect on K+ induced contraction was unaffected. The Rat ileum and Rat Stomach Strip has more pool of intracellular Ca2+ store than the RVD because in Ca medium, contraction declined markedly. The Vas Deferens showed unstable contraction in depolarised medium. The result of this study suggests that as membrane depolarization increases contraction in Rat Vas Deferens smooth muscle declined, while Verapamil and Nifedipine were more sensitive in blocking K+ than Ach and NA Induced contractions.

Keywords
Smooth muscle, Ileum, Stomach strip, Vas deferens, Contractions, Rat.

 
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