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Medicina
Croatian Medical Association - Rijeka branch
ISSN: 0025-7729
Vol. 41, No. 1, 2005, pp. 5-12
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Bioline Code: me05001
Full paper language: Croatian
Document type: Research Article
Document available free of charge
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Medicina, Vol. 41, No. 1, 2005, pp. 5-12
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Review - DEVELOPMENT AND STRUCTURAL PLASTICITY OF HUMAN BRAIN
Ivica Kostović, Nataša Jovanov-Milošević, Mirna Kostović-Srzentić, Zdravko Petanjek
Abstract
This review deals with recent evidence on vulnerability and the developmental
structural plasticity of the human brain: 1. Special laminar indicators of neurogenetic events and transitory fetal structure in preterm infants 2. New concept of vulnerability and organization of the white matter in preterms 3. Structural changes and abnormalities of the "white" matter of the
perinatal lesion
The correlation between MR images and the histological section
demonstrate typical fetal lamination: ventricular and subventricular
proliferative zones separated by periventricular fibrilar layer, intermediate
zone (fetal "white" matter), "subplate" zone with waiting and
growing fibers and cortical plate composed of migratory neurons. The
organization of white matter shows tangentional axonal strata in polar
regions of hemispheres and periventricular crossroads of commissural,
associative and projectional pathways. It is our opinion that pathogenetic
factors in hypoxic-ischemic lesions are not only restricted to
cellular and infections mechanisms, but they also include the disturbance
of extracellular matrix (ECM) and guidance molecules in
periventricular crossroads of pathways. The disturbance of ECM leads
to the reduction of commissural (especially corpus callosum), associative
and projectional pathways and consecutive poor cognitive and
neurological outcome. The results described in this review open new
possibilities in the diagnosis and follow up of perinatal lesions as well
as in the development of new strategies for neuroprotection.
Keywords
white matter, periventricular crossroads of pathways, developmental vulnerability, structural plasticity
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