Professional paper - EPILEPSY AMONG CHILDREN WITH CEREBRAL PALSY BORN IN RIJEKA BETWEEN 1982 AND 1992|
Ela Paućič-Kirinćič, Zlata Modrušan-Mozetič, Nada Sindičić-Šimundić, Igor Prpić, Martina Nekić
Children with CP often suffer from associated neurologic
problems and the association between CP and epilepsy is considered
to be an important issue.
Aim of study:
determination of prevalence, particularities, risk factors
and prognosis of epilepsy among children with CP
Patients and methods:
the study deals with children with CP and
epilepsy diagnosed according to the standard criteria, born in Rijeka in
the period between 1982 -
1992 and systematically followed at the
Centre for Children with Neurodevelopmental Problems.
The follow-up issues were: type of CP, timing of occurrence of epilepsy,
results of neuroimaging diagnostic, electroencephalography,
antiepileptic treatment modalities, prognosis of epilepsy.
Among 89 children with CP, 32 (35.9%) have associated
epilepsy, while 16 (50.0%) of them are with occurrence of epilepsy in
the first two years of life.
Neonatal seizures, sepsis and meningitis in 17 (53.1%) infants, pathologic
neuroimaging results in 27 (84.3%) and mental subnormality in
25 (78.1%) are increasing the risk of epilepsy in children with CP.
Epilepsy is much more frequent among children with spastic tetraplegia,
in 27 (84.3%). Infantile spasms and partial secondary generalised
seizures represent more than 50% of the epilepsy variation among
16 (53.3%) of 30 children were treated with antiepileptic politherapy.
Although severe epilepsy refractory to treatment was observed in 8
(26.6%) of patients, surprisingly it is 15 (50.0%) of children with
seizure-free periods that lasted for more than 5 years, while 16 (53.3%)
patients were treated with two or more antiepileptic drugs.
although in children with CP epilepsy is a life-long condition,
the use of new antiepileptic drugs which increase the seizure
free periods as well as the possibility of neurosurgical treatment, bring
more optimism in their families and promise a better quality of life.
epilepsy, cerebral palsy, treatment, follow-up