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Medicina
Croatian Medical Association - Rijeka branch
ISSN: 0025-7729
Vol. 43, No. 3, 2007, pp. 179-187
Bioline Code: me07025
Full paper language: Croatian
Document type: Research Article
Document available free of charge

Medicina, Vol. 43, No. 3, 2007, pp. 179-187

 en The Pathogenetic Mechanism In Delayed Onset Muscle Sorenes
Ravlić-Gulan, Jagoda; Vrbanić, Tea Schnurrer-Luke; Boschi, Vladimir & Vogrin, Matjaž

Abstract

Delayed onset muscle soreness (DOMS) is the feeling of pain, tenderness, deep ache and stiffness that usually develops 24-48 hours after an unaccustomed or a high intensity exercise and subsides generally within 5 to 7 days. Despite numerous studies there is no general consensus on the underlying mechanisms of DOMS, treatment or prevention strategies. A major causative factor is eccentric muscle actions, i.e. active resistance to muscle lengthening. However, the cellular basis for this response remains unclear. Eccentric activities induce micro-injury of muscle cells resulting in myofibrillar disruption, prolonged loss of muscle strength, decrements in motor control, changes in energy substrate levels and presence of muscle proteins in the blood. Some recent research claims that DOMS is not caused by the pain from damaged muscle cells and secondary induced inflammatory processes, but from the reinforcement process. The biological response of muscle to eccentric contractions results in strengthening and protection from further injury. The muscle responds to training by reinforcing itself up to and above its previous strength by adding new sarcomeres, the segments in the muscle fibrils (sarcomerogenesis). In this review, we summarize the muscle cell disturbances and adaptation processes known to be involved in pathogenetic mechanisms of DOMS which could be of clinical importance in sports medicine.

Keywords
delayed onset muscle soreness, eccentric contraction, sarcomerogenesis

 
 hr Patogenetski Mehanizam Sindroma Zakašnjele Mišićne Boli
Ravlić-Gulan, Jagoda; Vrbanić, Tea Schnurrer-Luke; Boschi, Vladimir & Vogrin, Matjaž


Zakašnjela (odgođena) mišićna bol (DOMS, od. engl. delayed onset muscle soreness) sindrom je koji obuhvaća slabost mišića, bol, duboku osjetljivost u mišićima koja se javlja obično 24–48 sati nakon neuobičajene ili jako intenzivne tjelesne aktivnosti, a prolazi za 5–7 dana. Usprkos brojnim studijama koje se bave ovom problematikom, još nisu usuglašeni stavovi ni o mogućem patogenetskom mehanizmu DOMS-a niti o terapijskim ili preventivnim mogućnostima. Kao glavni uzročni čimbenik pojave DOMS-a navodi se ekscentrična kontrakcija u kojoj se mišić tijekom održavanja napetosti produžuje, ali mehanizam koji to objašnjava nije poznat. Ekscentrična aktivnost mišića može inducirati ozljedu mišićne stanice, koja se manifestira kao oštećenje miofibrilarnih i citoskeletnih struktura, gubitak mišićne snage i poremećaj slijeda aktiviranja motoričkih jedinica, promjena metaboličkih zbivanja u stanici i izlazak enzima u cirkulaciju. Novija istraživanja govore o mogućnosti da bol nije uzrokovana isključivo mehaničkim oštećenjima mišićne stanice i sekundarnim upalnim odgovorima koji podražuje nociceptore, već adaptacijskim procesima remodeliranja mišićne stanice, kojima se povećava snaga mišića dodavanjem novih sarkomera (sarkomerogeneza) i time štiti mišić od novih ozljeda. U ovom radu donosimo pregled dosadašnjih spoznaja o promjenama u mišićnoj stanici, za koje se misli da su uključene u patofiziološki mehanizam nastanka odgođene boli u DOMS sindromu, a čije bi razjašnjavanje moglo imati široku kliničku primjenu u sportskoj medicini.


odgođena mišićna bol, ekscentrična kontrakcija, sarkomerogeneza

 
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Alternative site location: http://hrcak.srce.hr/medicina

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