Spontaneous Abortion After Assisted Reproductive Technology

Spontaneous abortion is defined as pregnancy loss before 20 weeks gestation, as based on last menstral period, or the delivery of a fetus that weights less than 500 g. Early pregnancy after assisted reproduction has increased risk for spontaneous abortion in confront of spontaneous pregnancies. There is no difference in etiologies of spontaneous abortion after IVF and the most common are genetic, anatomic, endocrine, infectious, autoimmune and other causes. The frequency of clinically recognized abortion is about 15 to 20% and chromosomal abnormalities cause at least half of them. With genetic counseling and preimplantation genetic diagnosis there is a possibility to decrease number of spontaneous abortion coused by genetic causes. Recently, as a consequence of new diagnostic technologies development there is increase of some other causes of early pregnancy loss as a antiphospholipid synrome (APS) and thombophilia.