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Medicina
Croatian Medical Association - Rijeka branch
ISSN: 0025-7729
Vol. 44, No. 1, 2008, pp. 16-21
Bioline Code: me08003
Full paper language: Croatian
Document type: Review Article
Document available free of charge

Medicina, Vol. 44, No. 1, 2008, pp. 16-21

 hr Farmakogenomika u terapiji akutnih limfatičnih leukemija u djece
Roganović, Jelena


Posljednjih desetljeća postignut je izvanredan napredak u liječenju akutnih limfatičnih leukemija u djece. Farmakogenomika akutnih leukemija izučava genetičku kontrolu mehanizama koji utječu na antileukemijski učinak lijekova i razvoja rezistencije na ove lijekove. Cilj farmakogenomike pedijatrijskih akutnih limfatičnih leukemija je identifikacija onih dijelova genoma koji su odgovorni za poželjne i nepoželjne učinke pojedinih citotoksičnih lijekova, u ovisnosti o individualnoj sposobnosti oboljelog djeteta da lijek iskoristi, metabolizira i eliminira. Stoga farmakogenomika pruža opravdanu nadu u mogućnost optimalizacije i individualizacije terapije, te daljnjeg poboljšanja rezultata liječenja djece s akutnom limfatičnom leukemijom.


akutna limfatična leukemija, dijete, farmakogenomika

 
 en Pharmacogenomics in the treatment of acute lymphoblastic leukemia in children
Roganović, Jelena

Abstract

Over the past decades, the treatment of acute lymphoblastic leukemia in children has made remarkable progress. Pharmacogenomics of acute leukemias elucidates mechanisms of genetic control of antileukemic effects of chemotherapy and development of drug resistance. The aim of pharmacogenomic studies, related to the treatment of pediatric acute lymphoblastic leukemias, is to identify genes responsible for drug efficacy and toxicity, matched with the genetic makeup of every individual child. Pharmacogenomics offers the reasonable promise of therapeutic optimization and individualization, and further improvement of treatment outcome in childhood lymphoblastic leukemia.

Keywords
acute lymphoblastic leukemia, child, pharmacogenomics

 
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