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Middle East Fertility Society Journal
Middle East Fertility Society
ISSN: 1110-5690
Vol. 9, No. 3, 2004, pp. 227-231
Bioline Code: mf04042
Full paper language: English
Document type: Research Article
Document available free of charge

Middle East Fertility Society Journal, Vol. 9, No. 3, 2004, pp. 227-231

 en Can serum prostate-specific antigen be a promising marker for patients with polycystic ovary syndrome and hirsutism
Ansam A.Al Bayatti, Summer H. Al-Samak, Awatif J. Al Bahar

Abstract

Background: Total prostatic specific antigen (TPSA) is a glycoprotein that is secreted from the prostate in males and from paraurethal glands and breast in females.
Objective: To evaluate the total prostate specific antigen (TPSA) in females with hirsutism and PCOS. In order to shade a light on its relation with FSH, LH, Prolactin (PRL), testosterone (testo) and estradiol (E2) as well as to hirsutism score and menstrual cycle disturbance. Setting:College of Medicine, University of Baghdad and Al-Alwia Hospital, Iraq.
Materials and Methods: Thirty five females with age range of 19-28 years and a mean of 25.3±2.3 years, suffering from PCOS and hirsutism that was classified according to Ferriman and Gallway scale, in approach, hair growth was judged in each of 11 androgen sensitive areas. Group I: score 4-8 consisted of 10 patients; Group II: score 8-12 consisted of 13 patients; and Group III: score 12-16 consisted of 12 patients. All patients with score above 16 were excluded from this study as well as patients with amenorrhea. They were evaluated clinically and by Sonar as well. FSH, LH, PRL, Testo and TPSA were estimated during second to third day of the cycle, while E2 and P were estimated during the midluteal phase using highly sensitive technique ELFA. Twenty fertile apparently healthy females with normal regular menstrual cycles without hirsutism were considered as control. Their age range 18-29 years with a mean of 25.5±2.8 years.
Results: TPSA mean SD was 2.67±0.37 ng/ml in hirsute females with PCOS which was significantly higher than control with a mean ± SD equal to 0.11±0.07 ng/ml (p<0.05). LF level was significantly higher in those patients, thus LH, FSH ratio 2.3±0.87 which was significantly higher in those patients (p<0.05) in comparison to control group. On the other hand P and E2 hormones during midluteal phase were significantly low in them with values 6.59±1.96 ng/ml and 87.55±21.61 pg/ml respectively (9<0.05). All other parameters including testo were more or less similar to control group. There was no significant correlation between TPSA and testo while the more the hirsutism score was the higher the TPSA level.
Conclusion:Serum TPSA level could be detectable in the serum of hirsute patients with PCOS by using ELFA technique, thus it could be a promising marker for such condition. It was noticed that the more the hirsutism score the higher the TPSA level.

Keywords
PCOS, TPSA, hirsutism, ELFA

 
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Alternative site location: http://www.mefsjournal.org

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