Multiple intravenous oxytocin injection may yield sperm in azoospermic men scheduled for TESE

Objective: The aim of the present trial is to evaluate the value of multiple IV injection of oxytocin in cryptospermic men scheduled for TESE/ICSI
Design: a prospective clinical trial
Materials and methods: Twenty eight infertile cryptospermic men were injected with 1.0 IU oxytocin IV daily for four successive days. Last injection was 20 minutes before collecting semen sample by masturbation. Data were then compared to their semen analysis one week before oxytocin injection (every case was its own self control).
Results: Motile spermatozoa were found in semen in 8 participants (28.6%). Number of sperm identified ranged between 1-5 motile sperm. Motility ranged from shaking movement to progressive movement. In cases where sperm showed any indication of movement, it was used for ICSI. TESE were performed in other subjects who yielded zero sperm. No difference in Blood pressure and pulse were recorded pre- and one hour post- injection. However, 5 cases complained of tension headache and hot flushes.
Conclusion: Multiple dose oxytocin injection in azoopermic men prior to ICSI may yield some spermatozoa, hence saving some cryptospermic men doing TESE.