Biochemical markers for prediction of pregnancy outcome in cases of recurrent pregnancy loss

Objective: To predict pregnancy outcome by studying the relation between serum βHCG, progesterone and CA125 and the occurrence of miscarriage in the first trimester, in cases with history of recurrent pregnancy loss.
Design: Prospective controlled trial.
Setting: Kasr- El-Aini Hospital and Galaa Hospital
Materials and methods: Serum βHCG, progesterone and CA125 levels in twenty pregnant women with history of recurrent pregnancy loss were compared to 20 pregnant women with no history of abortion, and to another group of women (No=20) who failed to complete the 1st trimester of pregnancy during the study.
Results: Serum B-hCG showed a sensitivity of 100%, a specificity of 50%, a PPV of 50% and a NPV of 100%. serum progesterone showed a sensitivity of 25%, a specificity of 78%, a PPV of 36% and a NPV of 67%, While serum CA125 showed a sensitivity of 10%, a specificity of 65%, a PPV of 13% and a NPV of 59%.
Conclusion: the value of CA125 in recurrent abortions is still unclear and cannot be recommended on routine basis. On the other hand β-HCG is 100% sensitive with a 50% NPV as a single serum measurement for the prediction of pregnancy outcome.