Resistin as a predictor for ovarian response to clomiphene citrate in obese PCOS women

Objective: to evaluate the value of resistin as a predictor of ovulation induction by clomiphene citrate in cases of PCOS.
Design: prospective, controlled clinical study
Setting: kasr Al-Aini Hospital
Materials and Methods: obese subfertile women with PCOS (BMI>30 kg/m2) received clomiphene citrate 50mg / 8hours from the third day of the cycle and for five days. Based on success of ovulation induction, women were divided into two groups: Group I who responded to CC and Group II: those who failed to respond to CC. Blood samples were collected on day 3 of the cycle and resistin, insulin and sugar were assayed .
Results: There was no significant difference between both groups regarding background characteristics, however, there was a significant difference regarding both BMI and resistin between both groups. Multiple linear regression showed a statistically significant value of resistin independent of that of BMI. The ROC curve showed a cut-off value of 4.78 for resistin with area under curve more than 78.9% and sensitivity 66.67% and specificity 82.4% to predict response to clomiphene citrate in obese PCOS women
Conclusion: in obese women, resistin may be of value in prediction of ovarian response to clomiphene citrate. This needs to be confirmed in further trials.