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Middle East Fertility Society Journal
Middle East Fertility Society
ISSN: 1110-5690
Vol. 12, No. 3, 2007, pp. 193-197
Bioline Code: mf07037
Full paper language: English
Document type: Research Article
Document available free of charge

Middle East Fertility Society Journal, Vol. 12, No. 3, 2007, pp. 193-197

 en Resistin as a predictor for ovarian response to clomiphene citrate in obese PCOS women
Alaa, Nadin; Noah, Olfat; Rizk, Ahmed; Hamdy, Enas & Al-Inany, Hesham


Objective: to evaluate the value of resistin as a predictor of ovulation induction by clomiphene citrate in cases of PCOS.
Design: prospective, controlled clinical study
Setting: kasr Al-Aini Hospital
Materials and Methods: obese subfertile women with PCOS (BMI>30 kg/m2) received clomiphene citrate 50mg / 8hours from the third day of the cycle and for five days. Based on success of ovulation induction, women were divided into two groups: Group I who responded to CC and Group II: those who failed to respond to CC. Blood samples were collected on day 3 of the cycle and resistin, insulin and sugar were assayed .
Results: There was no significant difference between both groups regarding background characteristics, however, there was a significant difference regarding both BMI and resistin between both groups. Multiple linear regression showed a statistically significant value of resistin independent of that of BMI. The ROC curve showed a cut-off value of 4.78 for resistin with area under curve more than 78.9% and sensitivity 66.67% and specificity 82.4% to predict response to clomiphene citrate in obese PCOS women
Conclusion: in obese women, resistin may be of value in prediction of ovarian response to clomiphene citrate. This needs to be confirmed in further trials.

resistin, PCOS, obesity, clomiphene citrate

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