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Middle East Fertility Society Journal
Middle East Fertility Society
ISSN: 1110-5690
Vol. 17, No. 1, 2012, pp. 37-41
Bioline Code: mf12007
Full paper language: English
Document type: Research Article
Document available free of charge

Middle East Fertility Society Journal, Vol. 17, No. 1, 2012, pp. 37-41

 en Infecund evaluation of cycling female Sprague–Dawley rats: An aftermath treatment with Momordica charantia check for this species in other resources seed extract
Amah, Chyke Ifeanyi; Yama, Oshiozokhai Eboetse & Noronha, Cressie Carmel


Introduction: Bitter melon ( Momordica charantia check for this species in other resources ) grows in tropical areas including parts of the Amazon, Africa, Asia and the Caribbean. It has an array of biologically active plant chemicals including triterpenes, proteins and steroids.
Aim: The aim is to evaluate the effect of methanolic seed extract of M. charantia (MC) on ova count, implantation and the fetus of Sprague–Dawley rats.
Methodology: Thirty adult cyclic female Sprague–Dawley (S–D) rats divided into three groups (A, B and C) of 10 rats/group were used for the study. The female rats in Groups B and C were made pregnant by cohabiting with male S–D rats. In all the groups, MC extract was administered in the morning (9.00 a.m.) at a dose of 25 mg/100 g b.w./oral. In Group A, rats (in proestrous phase) were treated with a single dose and sacrificed the following day (estrous phase). Rats in Group B were fed once daily from day 1 to 10 of gestation and sacrificed on the 12th day. Rats in Group C were fed once daily from day 6 to 19 of gestation and sacrificed on the 20th day of gestation. The following were assessed: ova count, anti–implantation, early abortifacient properties and possible teratogenicity.
Result: The extract completely suppressed the release of ova and exhibited highly significant anti-implantation activity. Significant (p< 0.05) changes were seen in the mean body weight, mean crown rump length and mean tail length of the fetuses.
Conclusion: In conclusion, MC (25 mg/100 g b.w.) exhibited anti-ovulatory and anti–implantation (early abortifacient) properties. These are certainly desirable anti–fertility actions. It also resulted in prenatal growth deficiencies.

Momordica charantia; Ova count; Abortifacient; Sprague–Dawley

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