Middle East Fertility Society Journal
Middle East Fertility Society
Vol. 17, No. 1, 2012, pp. 47-53
Bioline Code: mf12009
Full paper language: English
Document type: Research Article
Document available free of charge
Middle East Fertility Society Journal, Vol. 17, No. 1, 2012, pp. 47-53
© Copyright 2012 - Middle East Fertility Society
Effect of L-carnitine and meloxicam treatment on testicular leydig cell numbers of varicocelized rats|
Al-Rubiey, Fouad K.
Objective: Varicocele is a pathobiological condition associated with abnormal tortuosity
and dilatation of the veins of the pampiniform plexus within the spermatic cord; it is one of the leading
causes of male infertility. Although several studies have considered the relationship between varicocele
and semen L-carnitine concentrations, no study on the effects of L-carnitine on testicular
number of leydig cells which are important in fertility of the individual has been reported.
Design: Prospective study.
Setting: Institute of the Embryo Research and Infertility Treatment, College of Medicine,
Methods: Thirty male albino Wister rats divided into three groups, 10 animals each.
The groups A and B underwent a left experimental varicocele induction. Group C was not operated
on and served as control. Animals in group A (Treatment group) were treated with L-carnitine
twice daily and meloxicam once every four days. Group B (Placebo group) and C (Control group)
received placebo and distilled water, respectively; using the same treatment program of group A.
Treatment in all cases was given orally by oral cavage, and continued daily for 12 weeks. At the
end of treatment rats were sacrificed. Serial histological sections were then prepared and examined
microscopically for number of testicular leydig cells.
Main outcome measure: The number of Leydig cells was used to evaluate testicular changes:
Results: Histological examination shows new findings of significant improvement of decrease in the
number of leydig cells (P < 0.05) in treatment groups as compared to placebo.
Conclusion: It is concluded that L-carnitine plus meloxicam treatment appears to have a beneficial
effect in decreasing, restoring and maintaining the number of testicular leydig cells in experimental
varicocelized rats close to that control of non-varicocelized rats.
L-carnitine plus meloxicam; Varicocele; Rats; Leydig cells
Alternative site location: http://www.mefsjournal.org