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Malaysian Journal of Medical Sciences
School of Medical Sciences, Universiti Sains Malaysia
ISSN: 1394-195X
Vol. 9, No. 2, 2002, pp. 34-42
Bioline Code: mj02015
Full paper language: English
Document type: Research Article
Document available free of charge

Malaysian Journal of Medical Sciences, Vol. 9, No. 2, 2002, pp. 34-42

 en Role Of Vitamin E On Oxidative Stress In Smokers
Nafeeza Mohd. Ismail, Asma Harun, Ahmad Asmadi Yusof, Zaiton Z, and Alini Marzuki


Cigarette smoke contains numerous oxygen free radicals that when inhaled, overwhelm antioxidant defenses and produce a condition of oxidative stress. This study investigated whether or not supplementation with vitamin E can affect the state of oxidative stress in healthy smokers. In this randomised double blind trial, 32 smokers received 200 mg of vitamin E or placebo daily for 8 weeks. All smokers in the vitamin E group completed the trial whilst only nine in the placebo group completed the trial. Plasma vitamin E concentrations increased significantly [P<0.02] in the vitamin E group. The release of malondialdehyde [MDA] from erythrocytes was not significantly different between the two groups at baseline and was clearly reduced [P<0.01] after 8 weeks of vitamin E supplementation. Vitamin E increased erythrocyte superoxide dismutase activity [P<0.02] and decreased gluthathione peroxidase activity [P<0.02]. No changes were detected in plasma MDA. We conclude that daily supplementation with 200 mg of vitamin E for 8 weeks improved the oxidative stress state in smokers.

Vitamin E, smokers, oxidative stress, antioxidants

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