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REVIEW ARTICLE - An overview on the development of Newcastle disease virus as an anti-cancer therapy Abdul Rahman Omar, Aini Ideris, Abdul Manaf Ali, Fauziah Othman, Khatijah Yusoff, Jafri Malin Abdullah, Haryati Shila Mohamad Wali, Madihah Zawawi and Narayani Meyyappan Abstract Newcastle disease virus (NDV) is one of the most economically important avian virus which affects the poultry industry worldwide. Although NDV is being very actively studied in Malaysia, there are still no studies on its potential as an anticancer agent, a new approach to treating cancer known as virotherapy. Currently, a collaborative research is being undertaken between Universiti Putra Malaysia (UPM), Universiti Sains Malaysia (USM) and Majlis Kanser Nasional (MAKNA) in characterising various local NDV isolates as anticancer agent. This paper describes an overview of the research that have been carried out worldwide in the use of NDV for cancer treatment and also some of our findings in characterising local NDVs with oncolytic properties. Keywords Newcastle disease virus, anticancer agent, apoptosis

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