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Malaysian Journal of Medical Sciences
School of Medical Sciences, Universiti Sains Malaysia
ISSN: 1394-195X
Vol. 10, No. 1, 2003, pp. 4-12
Bioline Code: mj03002
Full paper language: English
Document type: Research Article
Document available free of charge

Malaysian Journal of Medical Sciences, Vol. 10, No. 1, 2003, pp. 4-12

 en REVIEW ARTICLE - An overview on the development of Newcastle disease virus as an anti-cancer therapy
Abdul Rahman Omar, Aini Ideris, Abdul Manaf Ali, Fauziah Othman, Khatijah Yusoff, Jafri Malin Abdullah, Haryati Shila Mohamad Wali, Madihah Zawawi and Narayani Meyyappan

Abstract

Newcastle disease virus (NDV) is one of the most economically important avian virus which affects the poultry industry worldwide. Although NDV is being very actively studied in Malaysia, there are still no studies on its potential as an anticancer agent, a new approach to treating cancer known as virotherapy. Currently, a collaborative research is being undertaken between Universiti Putra Malaysia (UPM), Universiti Sains Malaysia (USM) and Majlis Kanser Nasional (MAKNA) in characterising various local NDV isolates as anticancer agent. This paper describes an overview of the research that have been carried out worldwide in the use of NDV for cancer treatment and also some of our findings in characterising local NDVs with oncolytic properties.

Keywords
Newcastle disease virus, anticancer agent, apoptosis

 
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Alternative site location: http://www.medic.usm.my/publication/mjms/

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