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Malaysian Journal of Medical Sciences
School of Medical Sciences, Universiti Sains Malaysia
ISSN: 1394-195X
Vol. 11, No. 1, 2004, pp. 9-23
Bioline Code: mj04002
Full paper language: English
Document type: Research Article
Document available free of charge

Malaysian Journal of Medical Sciences, Vol. 11, No. 1, 2004, pp. 9-23

 en REVIEW ARTICLE - Cell Targeting in Anit-Cancer Gene Therapy
Mohd Azmi Mohd Lila, John Shia Kwong Siew, Hayati Zakaria, Suria Mohd Saad, Lim Shen Ni and Jafri Malin Abdullah

Abstract

Gene therapy is a promising approach towards cancer treatment. The main aim of the therapy is to destroy cancer cells, usually by apoptotic mechanisms, and preserving others. However, its application has been hindered by many factors including poor cellular uptake, non-specific cell targeting and undesirable interferences with other genes or gene products. A variety of strategies exist to improve cellular uptake efficiency of gene-based therapies. This paper highlights advancements in gene therapy research and its application in relation to anti-cancer treatment.

Keywords
Gene therapy, anti-cancer, cell targeting, apoptosis

 
© Copyright 2004 - Malaysian Journal of Medical Science
Alternative site location: http://www.medic.usm.my/publication/mjms/

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