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Malaysian Journal of Medical Sciences
School of Medical Sciences, Universiti Sains Malaysia
ISSN: 1394-195X
Vol. 11, No. 1, 2004, pp. 37-43
Bioline Code: mj04004
Full paper language: English
Document type: Research Article
Document available free of charge

Malaysian Journal of Medical Sciences, Vol. 11, No. 1, 2004, pp. 37-43

 en REVIEW ARTICLE - What we Know About Molecular Genetics of Central Nervous System (CNS) Tumours in Malysia
Sarina Sulong, Abdul Aziz Mohamed Yusoff, Norafiza Zainuddin, Jafri Malin Abdullah, Jain George Pannatil, Hasnan Jaafar, Mohd Nizam Isa


The new millennium has been regarded as a genomic era. A lot of researchers and pathologists are beginning to understand the scientific basis of molecular genetics and relates with the progression of the diseases. Central nervous system (CNS) tumours are among the most rapidly fatal of all cancers. It has been proposed that the progression of malignant tumours may result from multi-step of genetic alterations, including activation of oncogenes, inactivation of tumour suppressor genes and also the presence of certain molecular marker such as telomerase activity. In this paper, we review some recent data from the literature, including our own studies, on the molecular genetics analysis in CNS tumours. Our studies have shown that two types of tumour suppressor genes, p53 and PTEN were involved in the development of these tumours but not in p16 gene among the patients from Hospital Universiti Sains Malaysia (HUSM). Telomerase activity also has been detected in various types of CNS tumours. Thus, it is important to assemble all data which related to this study and may provide as a vital information in a new approach to neuro-oncology studies in Malaysia.

molecular genetics, CNS tumours, Malaysia

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