About Bioline  All Journals  Testimonials  Membership  News  Donations

Malaysian Journal of Medical Sciences
School of Medical Sciences, Universiti Sains Malaysia
ISSN: 1394-195X
Vol. 12, No. 2, 2005, pp. 22-26
Bioline Code: mj05016
Full paper language: English
Document type: Research Article
Document available free of charge

Malaysian Journal of Medical Sciences, Vol. 12, No. 2, 2005, pp. 22-26

Sharifa Abdul Aziz, Tan Lee See, Lim Yew Khuay, Khairul Osman, Mohd. Azman Abu Bakar


The study was carried out to determine the in vitro effect of Plantago major extract on calcium oxalate crystals and to compare the effects of Plantago major extract with clinically used drugs like allopurinol and potassium citrate (positive controls). Modified Schneider slide gel method was used for the in vitro study and the crystals formed were measured by Image Analyser system KS 300, 3.0 Carl Zeiss. The concentrations of Plantago major extract used were from 100ppm to 350ppm. Plantago major extract at concentrations in the range of (100ppm-350ppm) significantly inhibited the size of calcium oxate crystals (dihydrate variety) against negative control (p<0.05) and against positive controls(p<0.05). However the inhibition concentration 50 (IC50) values on the size of calcium oxalate crystal for the extract, potassium citrate and allopurinol were 300ppm, 350ppm and 450ppm respectively. Extract of Plantago major also has inhibition effect on the number of crystals but it was not significant. In conclusion extract of Plantago major was better than allopurinol and potassium citrate in inhibiting the size of the calcium oxalate crystal in-vitro.

Labisia pumila var. alata, aqueous extract, teratogenicity

© Copyright 2005 - Malaysian Journal of Medical Science
Alternative site location:

Home Faq Resources Email Bioline
© Bioline International, 1989 - 2019, Site last up-dated on 02-May-2019.
Site created and maintained by the Reference Center on Environmental Information, CRIA, Brazil
System hosted by the Internet Data Center of Rede Nacional de Ensino e Pesquisa, RNP, Brazil