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Malaysian Journal of Medical Sciences
School of Medical Sciences, Universiti Sains Malaysia
ISSN: 1394-195X
Vol. 15, No. 2, 2008, pp. 43-46
Bioline Code: mj08018
Full paper language: English
Document type: Case Report
Document available free of charge

Malaysian Journal of Medical Sciences, Vol. 15, No. 2, 2008, pp. 43-46

 en Molecular Genetic Analysis Of A Suprasellar Immature Teratoma : Mutation Of Exon 4 P53 Gene
Udin, Nujaimin; Ahmad, Ku Asmarina Ku; Ahmad, Farizan; Omar, Effat; Aziz, Mohd Ezanee; Kumar, Raj & Abdullah, Jafri Malin

Abstract

We described an intracranial immature teratoma in a 13 year old Malay boy who presented with history of chronic headache and blurring of vision. Physical findings revealed bilateral papilloedema but no other localizing sign. A Magnetic Resonance Imaging of the brain revealed a suprasellar well defined lobulated midline heterogenous mass which was intraoperatively described as mainly solid tumour with multiple small cystic component filled with yellowish jelly like material. Histopathological finding confirmed the case as immature teratoma. Molecular genetic analysis of p53 and p27 genes revealed substitution of nucleotide G to C at location nucleotide 12139, exon 4 of gene p53. No alteration was detected at exon 5-6 and 8 of p53 gene and exon 1 and 2 of p27 gene. This is the first case report of an intracranial immature teratoma with genetic mutation occuring in a Malay boy.

Keywords
Teratoma, Immature, Suprasellar, Genetic Analysis

 
© Copyright 2008 - Malaysian Journal of Medical Science
Alternative site location: http://www.medic.usm.my/publication/mjms/

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