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Malaysian Journal of Medical Sciences
School of Medical Sciences, Universiti Sains Malaysia
ISSN: 1394-195X
Vol. 15, No. 3, 2008, pp. 22-30
Bioline Code: mj08023
Full paper language: English
Document type: Research Article
Document available free of charge

Malaysian Journal of Medical Sciences, Vol. 15, No. 3, 2008, pp. 22-30

 en Evaluation of the histo-gastroprotective and antimicrobial activities of Heliotropium indicum check for this species in other resources Linn (Boraginaceae)
Adelaja, Akinlolu Abdulazeez; Ayoola, M. D.; Otulana, J. O.; Akinola, O. B.; Olayiwola, Abimbola & Ejiwunmi, A. B.

Abstract

Heliotropium indicum check for this species in other resources of the family Boraginaceae is used locally in Nigeria to treat ailments such as ulcer and fever. In this study, ulceration of the gastric mucosa in Wistar rats was induced via the oral administration of 80mg/kg/bodyweight of Indomethacin. Histological analyses of the stomach body wall in the rats of Groups 2 and 4 (which received 100mg/kg/bodyweight of extract before oral administration of 80mg/kg/bodyweight Indomethacin and 80mg/kg/bodyweight Indomethacin only respectively) showed erosion of the mucus-secreting cells, gastric pit, upper and middle parts of gastric glands and some of the parietal cells. Histological observations of the stomach body wall in rats of Group 5 (which received 200mg/ kg/bodyweight of extract before oral administration of 80mg/kg/bodyweight of Indomethacin) showed erosion of the mucus-secreting cells, gastric pit and the upper most part of the gastric gland. Histological observations of the stomach body wall in rats of Groups 1, 6 and 3 (which received 50mg/kg/bodyweight of Ranitidine and 400mg/kg/bodyweight of extract before oral administration of 80mg/ kg/bodyweight Indomethacin; and only 80mg/kg/bodyweight of Normal Saline respectively) showed normal morphological appearance of the different components of the mucosa layer. Thus, the aqueous extracts of the dried leaves of Heliotropium indicum have dose dependent histo-gastroprotective effects.

Keywords
Heliotropium Indicum, Ulcerated Gastric Mucosa, Histo-Gastroprotective Effects

 
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Alternative site location: http://www.medic.usm.my/publication/mjms/

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