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Malaysian Journal of Medical Sciences
School of Medical Sciences, Universiti Sains Malaysia
ISSN: 1394-195X
Vol. 16, No. 3, 2009, pp. 13-21
Bioline Code: mj09019
Full paper language: English
Document type: Research Article
Document available free of charge

Malaysian Journal of Medical Sciences, Vol. 16, No. 3, 2009, pp. 13-21

 en Influence of CYP2D6 polymorphisms on symptomatology and side-effects of patients with schizophrenia in Malaysia
Zahari, Zalina; Salleh, Mohd Razali; Teh, Lay Kek & Ismail, Rusli

Abstract

Background: Our objective was to investigate the association of CYP2D6 polymorphisms with symptoms and side-effects of patients with schizophrenia.

Methods: The subjects were 156 patients with schizophrenia undergoing antipsychotic treatment at a psychiatric clinic. Patients with co-morbid diagnoses of substance abuse or mental retardation were excluded from the study. Psychopathology was evaluated using the Positive and Negative Symptoms Scale (PANSS). Extrapyramidal side-effects and akathisia were assessed with the Simpson Angus Scale (SAS) and the Barnes Akathisia Rating Scale (BARS), respectively. DNA was extracted from blood and subjected to PCR-genotyping.

Results: We found that CYP2D6 polymorphisms were significantly associated with a subtotal negative PANSS score. In addition, CYP2D6 is not related to side-effects of antipsychotic therapy, or SAS and BARS scores. The results suggest that CYP2D6 polymorphisms may have implications in treatment response.

Conclusions: Therefore, CYP2D6 may be a predictor for treatment outcomes of patients with schizophrenia. However, further investigation is required to confirm these findings in a larger sample.

Keywords
Cytochrome P450 CYP2D6, schizophrenia, treatment outcomes

 
© Copyright 2009 - Malaysian Journal of Medical Science
Alternative site location: http://www.medic.usm.my/publication/mjms/

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