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Malaysian Journal of Medical Sciences
School of Medical Sciences, Universiti Sains Malaysia
ISSN: 1394-195X
Vol. 17, No. 2, 2010, pp. 45-50
Bioline Code: mj10020
Full paper language: English
Document type: Case Report
Document available free of charge

Malaysian Journal of Medical Sciences, Vol. 17, No. 2, 2010, pp. 45-50

 en Gastric Schwannoma in a Female Patient with Pulmonary Tuberculosis-A Clinicopathological Assessment and Diagnosis
Tahir, Tariq Mahmood; Anwar, Sadia; Naseem, Nadia; Mansoor-Ul-Haq, Hafiz & Saqib, Muhammad

Abstract

Schwannomas, or neurinomas, are generally benign, slow-growing, asymptomatic neoplasms originating from the Schwann cells of a nerve sheath. As a part of spindle cell mesenchymal tumours, schwannomas arising from the gastrointestinal tract (GIT) are unusual; however, when they occur, the most common site involved is the stomach, which represents 0.2% of all gastric tumours. We report the case of a 35-year-old female patient with a history of pulmonary tuberculosis presenting with a large palpable abdominal mass reaching up to the peritoneal cavity. The initial clinical impression was a tuberculous abdominal mass, a cyst, or a teratoma. However, intra-operative findings during a subtotal gastrectomy revealed an exophytic gastric serosal mass, which suggested a gastrointestinal stromal tumour (GIST). Post-operative histopathological findings showed a fascicular arrangement of neoplastic spindle cells with pallisading nuclei that showed intense positivity for S-100 protein, and were negative for CD117 and desmin in immunohistochemistry studies. These results confirmed the final diagnosis of a gastric schwannoma.

Keywords
gastrointestinal stromal tumours, immunohistocytochemistry, neurilemmoma, stomach, medical sciences

 
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Alternative site location: http://www.medic.usm.my/publication/mjms/

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