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Malaysian Journal of Medical Sciences
School of Medical Sciences, Universiti Sains Malaysia
ISSN: 1394-195X
Vol. 17, No. 3, 2010, pp. 5-12
Bioline Code: mj10026
Full paper language: English
Document type: Review Article
Document available free of charge

Malaysian Journal of Medical Sciences, Vol. 17, No. 3, 2010, pp. 5-12

 en Genetic Aberrations in Childhood Acute Lymphoblastic Leukaemia: Application of High-Density Single Nucleotide Polymorphism Array
Sulong, Sarina


Screening of the entire human genome using high-density single nucleotide polymorphism array (SNPA) has become a powerful technique used in cancer genetics and population genetics studies. The GeneChip® Mapping Array, introduced by Affymetrix, is one SNPA platform utilised for genotyping studies. This GeneChip system allows researchers to gain a comprehensive view of cancer biology on a single platform for the quantification of chromosomal amplifications, deletions, and loss of heterozygosity or for allelic imbalance studies. Importantly, this array analysis has the potential to reveal novel genetic findings involved in the multistep development of cancer. Given the importance of genetic factors in leukaemogenesis and the usefulness of screening the whole genome, SNPA analysis has been utilised in many studies to characterise genetic aberrations in childhood acute lymphoblastic leukaemia.

B- and T-cell acute lymphoblastic leukaemia, child, cytogenetic aberrations, single nucleotide polymorphisms, oligonucleotide array sequence analysis, medical sciences

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