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Malaysian Journal of Medical Sciences
School of Medical Sciences, Universiti Sains Malaysia
ISSN: 1394-195X
Vol. 19, No. 2, 2012, pp. 5-18
Bioline Code: mj12016
Full paper language: English
Document type: Review Article
Document available free of charge

Malaysian Journal of Medical Sciences, Vol. 19, No. 2, 2012, pp. 5-18

 en Cytoadherence and Severe Malaria
Craig , Alister G.; Khairul , Mohd Fadzli Mustaffa & Patil , Pradeep R.


Malaria is a disease that causes enormous human morbidity and mortality. One feature of mature Plasmodium falciparum check for this species in other resources -infected erythrocytes leading to the development of severe malaria is thought to be cytoadherence and blockage of the microvasculature. Therefore, an understanding of mechanisms that mediate parasite adhesion leading to malaria pathology is needed to yield new treatments for malaria. However, to date, cytoadherence-associated pathology is still under debate. Is cytoadherence needed to develop severe malaria? This review will discuss the available information on associations of cytoadherence with the development of severe malaria.

cerebral malaria, cytoadherence, endothelium, malaria

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