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Malaysian Journal of Medical Sciences
School of Medical Sciences, Universiti Sains Malaysia
ISSN: 1394-195X
Vol. 20, No. 1, 2013, pp. 76-80
Bioline Code: mj13010
Full paper language: English
Document type: Short Communication
Document available free of charge

Malaysian Journal of Medical Sciences, Vol. 20, No. 1, 2013, pp. 76-80

 en The Impact of Chimerism in DNA-based Forensic Sex Determination Analysis
George, Renjith; Donald, Preethy Mary; Nagraj, Sumanth Kumbargere; Idiculla, Jose Joy & Ismail, Rashid Hj


Sex determination is the most important step in personal identification in forensic investigations. DNA-based sex determination analysis is comparatively more reliable than the other conventional methods of sex determination analysis. Advanced technology like real-time polymerase chain reaction (PCR) offers accurate and reproducible results and is at the level of legal acceptance. But still there are situations like chimerism where an individual possess both male and female specific factors together in their body. Sex determination analysis in such cases can give erroneous results. This paper discusses the phenomenon of chimerism and its impact on sex determination analysis in forensic investigations.

DNA, chimerism, forensic sciences, polymerase chain reaction, sex determination analysis

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