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Malaysian Journal of Medical Sciences
School of Medical Sciences, Universiti Sains Malaysia
ISSN: 1394-195X
Vol. 21, No. 1, 2014, pp. 4-10
Bioline Code: mj14002
Full paper language: English
Document type: Review Article
Document available free of charge

Malaysian Journal of Medical Sciences, Vol. 21, No. 1, 2014, pp. 4-10

 en Pathogenesis and Immune Response in Tuberculous Meningitis
Isabel, Bini Estela & Rogelio, Hernández Pando

Abstract

Cerebral tuberculosis is the most severe type of extrapulmonary disease that is in developing countries highly predominant in children. Meningeal tuberculosis is the most common form and usually begins with respiratory infection followed by early haematogenous dissemination to extrapulmonary sites involving the brain. In comparison with the lung, Mycobacterium tuberculosis check for this species in other resources induces a very different immune response when infect the central nervous system. Herein, we review several aspects of the pathogenesis and immune response in pulmonary and cerebral tuberculosis in humans and experimental models and discuss the implications of this response in the cerebral infection outcome.

Keywords
tuberculosis; tuberculous meningitis; cerebrospinal fluid

 
© Malaysian Journal of Medical Sciences
Alternative site location: http://www.medic.usm.my/publication/mjms/

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