Association of Thyroid Profile and Prolactin Level in Patient with Secondary Amenorrhea|
Shrestha, Sujata; Neupane, Sunita; Gautam, Narayan; Dubey, Raju Kumar; Jha, Amit Chandra; Doshi, Nilesh Raj & Jayan, Archana
Background: Amenorrhea is the absence of menstrual periods. It has multiple social
consequences as it may leads to infertility. This case control study was conducted for determining
the association of thyroid hormones with hyperprolactinemia in patient with amenorrhea.
Methods: We investigated 50 women with diagnosed cases of secondary amenorrhoea,
who attended UCMS hospital, for hormonal evaluations. Fifty two healthy women were taken as
the controls. The thyroid dysfunction and serum prolactin level were reviewed in cases and in the
Results: Mean serum prolactin level was found to be significantly higher in the cases as
compared to the controls. Mean serum fT3 and fT4 level in the hyperprolactinemic cases (mean
= 2.67, SD = 1.04 pg/ml) and (mean = 1.38, SD = 0.51 ng/dl respectively) were slightly lower as
compared to normoprolactinemic cases (mean = 3.21, SD = 1.86 pg/ml) and (mean = 1.73,
SD = 1.37 ng/dl) respectively. Mean TSH of normoprolactinemic and hyperprolactinemic cases
were comparable (P = 0.049). There was positive correlation between prolactin, BMI and TSH
whereas negative correlation of prolactin was seen with fT3, fT4 and age. In hyperprolactainemic
cases, prolactin was found to be negatively correlated with TSH (r = -0.155, P = 0.491) whereas
prolactin was positively correlated with TSH (r = 0.296, P = 0.126) in normoprolactainemic cases.
Conclusions: Thus, hyperprolactinemia with thyroid dysfunction may be contributory
hormonal factor in patient with amenorrhoea and as such, estimation of prolactin, fT3, fT4 and
TSH should be included for diagnostic evaluation of amenorrhea.
Amenorrhea; prolactin; Thyroid Stimulating Hormone (TSH)