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Malaysian Journal of Medical Sciences
School of Medical Sciences, Universiti Sains Malaysia
ISSN: 1394-195X
Vol. 24, No. 1, 2016, pp. 113-116
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Bioline Code: mj17012
Full paper language: English
Document type: Case Report
Document available free of charge
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Malaysian Journal of Medical Sciences, Vol. 24, No. 1, 2016, pp. 113-116
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Paraneoplastic Neurological Disorder in Nasopharyngeal Carcinoma
Ng, Sze Yin; Kong, Min Han & Mohamad Yunus, Mohd Razif
Abstract
Paraneoplastic neurological disorder (PND) is a condition due to immune cross-reactivity
between the tumour cells and the normal tissue, whereby the “onconeural” antibodies attack the
normal host nervous system. It can present within weeks to months before or after the diagnosis
of malignancies. Nasopharyngeal carcinoma is associated with paraneoplastic syndrome, for
example, dermatomyositis, and rarely with a neurological disorder. We report on a case of
nasopharyngeal carcinoma with probable PND. Otolaryngologists, oncologists and neurologists
need to be aware of this condition in order to make an accurate diagnosis and to provide prompt
treatment.
Keywords
nasopharyngeal; carcinoma; neurological disorder; paraneoplastic syndrome; nervous system; paraneoplastic polyneuropathy; PND
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