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Malaysian Journal of Medical Sciences
School of Medical Sciences, Universiti Sains Malaysia
ISSN: 1394-195X
Vol. 24, No. 2, 2017, pp. 6-20
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Bioline Code: mj17016
Full paper language: English
Document type: Review Article
Document available free of charge
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Malaysian Journal of Medical Sciences, Vol. 24, No. 2, 2017, pp. 6-20
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Drosophila melanogaster : Deciphering Alzheimer's Disease
Hui Ping Tan, Florence & Azzam, Ghows
Abstract
Alzheimer's disease (AD) is the most widespread neurodegenerative disorder worldwide.
Its pathogenesis involves two hallmarks: aggregation of amyloid beta (Aβ) and occurrence of
neurofibrillary tangles (NFTs). The mechanism behind the disease is still unknown. This has
prompted the use of animal models to mirror the disease. The fruit fly, Drosophila melanogaster
has garnered considerable attention as an organism to recapitulate human disorders. With
the ability to monopolise a multitude of traditional and novel genetic tools, Drosophila is ideal
for studying not only cellular aspects but also physiological and behavioural traits of human
neurodegenerative diseases. Here, we discuss the use of the Drosophila model in understanding
AD pathology and the insights gained in discovering drug therapies for AD.
Keywords
Alzheimer; Drosophila; model organism
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© Copyright 2017 - Penerbit Universiti Sains Malaysia Alternative site location: http://www.medic.usm.my/publication/mjms/
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