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Malaysian Journal of Medical Sciences
School of Medical Sciences, Universiti Sains Malaysia
ISSN: 1394-195X
Vol. 24, No. 2, 2017, pp. 21-27
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Bioline Code: mj17017
Full paper language: English
Document type: Research Article
Document available free of charge
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Malaysian Journal of Medical Sciences, Vol. 24, No. 2, 2017, pp. 21-27
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A Combination of Trimethoprim-sulfamethoxazole and Ceftazidime Showed Good In Vitro Activity against Stenotrophomonas maltophilia
Ismail, Nabilah; Zam, Zarifah; Hassan, Siti Asma & Abdul Rahman, Zaidah
Abstract
Background: Stenotrophomonas maltophilia has emerged as an important nosocomial
pathogen, capable of causing a wide spectrum of infections. Treatment is difficult because it is
resistant to many antimicrobial agents, thus reducing the treatment options. The aims of this
study were to describe the antimicrobial susceptibility patterns and synergistic effect of selected
antimicrobial combinations against S. maltophilia isolates.
Methods: This was a descriptive cross-sectional study undertaken in the Hospital
Universiti Sains Malaysia from April 2011 to March 2012. S. maltophilia isolated from various
clinical specimens were included in the study. Antimicrobial susceptibility testing was done
using the epsilometer test (E-test) and interpreted according to the guidelines of the Clinical and
Laboratory Standards Institute. In the synergy test, the isolates were tested against six different
antimicrobial combinations.
Results: In total, 84 S. maltophilia isolates were collected and analysed. According
to the E-test, the antimicrobial susceptibility of trimethoprim-sulfamethoxazole (TMP-SMX),
tigecycline, and ciprofloxacin was 100%, 91.1%, and 88.9% respectively. The antimicrobial
combination of TMP-SMX and ceftazidime showed the highest synergistic effect.
Conclusion: TMP-SMX remains the antimicrobial of choice to treat S. maltophilia
infection. TMP-SMX and ceftazidime was the most effective combination in vitro.
Keywords
combination; trimethoprim-sulfamethoxazole; ceftazidime; Stenotrophomonas maltophilia
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