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Malaysian Journal of Medical Sciences
School of Medical Sciences, Universiti Sains Malaysia
ISSN: 1394-195X
Vol. 24, No. 2, 2017, pp. 28-32
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Bioline Code: mj17018
Full paper language: English
Document type: Research Article
Document available free of charge
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Malaysian Journal of Medical Sciences, Vol. 24, No. 2, 2017, pp. 28-32
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Soluble Fas Ligand as a Potential Marker of Severity of Dengue Infection
Zain, Nurfadly; Taat Putra, Suhartono; Zein, Umar & Hariman, Herman
Abstract
Background: The apoptosis of microvascular endothelial cells causes plasma leakage in
dengue haemorrhagic fever patients. The soluble Fas ligand is a protein with molecular weight
of 40 kDa that acts as a mediator of apoptosis. This study aimed to prove whether soluble Fas
ligand can be used as a potential marker to predict the severity of dengue infection by comparing
the soluble Fas ligand levels in dengue fever (DF) and dengue haemorrhagic fever (DHF) patients
early in the course of illness.
Method: This was a prospective study. It included 42 dengue patients (22 DF patients and
20 DHF patients) and 20 healthy people as a control group. The soluble Fas ligand was measured
by the enzyme-linked immunosorbent assay (ELISA).
Result: Soluble Fas ligand was increased significantly (P < 0.001) in DHF patients
(median = 130.19, IQR = 36.26) compared to DF patients (median = 104.73, IQR = 53.94) and the
control group (median = 87.16, IQR = 24.91).
Conclusion: Soluble Fas ligand can be used as a potential marker to predict the severity
of dengue infection in the early course of the illness. However, a larger sample size and further
objective studies are needed to confirm these findings.
Keywords
dengue fever; dengue hemorrhagic fever; Fas ligand
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© Copyright 2017 - Penerbit Universiti Sains Malaysia Alternative site location: http://www.medic.usm.my/publication/mjms/
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