en

The Effect of 4-hydroxybenzaldehyde on the γ-aminobutyric Acid Type A Receptor Zhang, Jingli; Mohamad, Habsah; Wong, Jia Hui; Bilal, Muhammad; Ismail, Abdul Hadi Bin; Lloyd, Amelia Jane; Mohamed Yusoff, Abdul Aziz; Osman, Hasnah; Wong, Kok Tong; Idris, Zamzuri & Abdullah, Jafri Malin Abstract   The α1β2γ2 subtype of GABAA receptors is the most commonly found GABAA receptor subtype in the mammalian cortex and hippocampus. It is expressed heterologously in the Xenopus laevis oocyte as a α1β2γ2S/L subtype for application as an in vitro model for the screening of compounds that modulate receptor activities. In fact, 4-hydroxybenzaldehyde (4-HB) has been identified as one of the major components in Dendrocalamus asper bamboo shoots in our previous study, and the current study showed that at 101.7 μM, 4-HB significantly reduced the GABA-induced chloride current of GABAA receptors expressed on Xenopus oocytes, indicating a possible GABAergic antagonistic effect at high concentrations. Keywords α1β2γ2 GABAA receptor; electrophysiology; Xenopus oocytes; bamboo shoot; GABAergic agents

© Copyright 2017 - Penerbit Universiti Sains Malaysia
Alternative site location: http://www.medic.usm.my/publication/mjms/