Comparing Lavage of the Peritoneal Cavity with Lidocaine, Bupivacaine and Normal Saline to Reduce the Formation of Abdominal Adhesion Bands in Rats|
Parsa, Hossein; Saravani, Hengameh; Sameei-Rad, Fatemeh; Nasiri, Marjan; Farahaninik, Zahra & Rahmani, Amirhossein
Background: Intra-abdominal adhesions are fibrous bands that develop after abdominal
surgery or inflammation and cause mortality and morbidity following surgeries. This study aimed
to assess the effects of bupivacaine, saline and two doses of lidocaine, after peritoneal lavage and
to compare their effects in reducing abdominal adhesions in rat.
Methods: In a blinded, randomised, placebo-controlled clinical trial, 50 female rats were
anaesthetised and the parietal peritoneum was scratched to induce punctate bleeding. The rats
were randomly assigned to five groups: saline, lidocaine 2% (3 and 6 mg/kg), bupivacaine 0.25%
(2 mg/kg) and control (no irrigation). The peritoneal cavity was irrigated with the appropriate
solution during laparotomy. Two weeks later, re-laparotomy was performed. The quantity,
quality, severity and scores of adhesions were recorded and compared.
Results: The quantity and quality of adhesions were significantly higher in the control
group than in the lidocaine (6 mg/kg) and bupivacaine groups. The quality of the adhesions was
higher in the normal saline group than in the lidocaine (6 mg/kg) and bupivacaine groups. The
severity of adhesions between the lidocaine 3 and 6 mg/kg groups and between the lidocaine 3 mg/
kg and saline groups was lower than that in the control group.
Conclusion: Using lidocaine (6 mg/kg) and bupivacaine lavage in first laparotomy reduces
abdominal peritoneal obstruction because of the formation of adhesion bands.
adhesion; lidocaine; peritoneal lavage