Nutritional Compositions and Antiproliferative Activities of Different Solvent Fractions from Ethanol Extract of Cyphomandra betacea (Tamarillo) Fruit|
Abdul Mutalib, Maisarah; Rahmat, Asmah; Ali, Faisal; Othman, Fauziah & Ramasamy, Rajesh
Background: This study aims to examine various solvent extracts of Cyphomandra
betacea (tamarillo) also known as the tree tomato, for their bioactive constituents and antioxidant
activity. The study also aims to examine its effect on cancer cell death using two types of cancer
cell lines (liver and breast cancer cell).
Methods: The first part of the study evaluates the nutritional composition of tamarillo.
Then, phytochemical profiling using GC-MS analysis in ethanolic tamarillo extract was conducted.
Different fractions of n-butanol, ethyl acetate and aqueous fractions were obtained from the
ethanolic extract of tamarillo. Then, the fractions were subjected to the quantification of total
phenol (TPC) and flavonoid contents (TFC), free radical scavenging activity (SA) and also
antioxidant activity (AOX) assayed by beta-carotene bleaching (BCB) assay. Finally, the capability
of the ethanolic extract of tamarillo and different fractions were evaluated for their anticancer
Results: Findings from this study revealed that the nutritional composition (ash, protein,
carbohydrate and total dietary fiber), and mineral levels (calcium, magnesium, potassium and
iron) of tamarillo were moderate. The crude ethanol extract of tamarillo contained the highest
phenolic and total flavonoid content. FT-IR analysis revealed the presence of alkanes, carboxylic
acid, phenol, alkanes, carboxylic acids, aromatics and nitro compounds. Twelve bioactive
constituents in tamarillo have been identified through GC-MS analysis. Cytotoxic activity suggests
the potential of ethanolic extracts of tamarillo having a chemopreventive effect on breast and liver
Conclusion: This study reveals that tamarillo has substantial antioxidant activity as well
as anticancer properties.
Cyphomandra betaceae; nutritional composition; antioxidant activity; anticancer activities; antiproliferative activities