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Malaysian Journal of Medical Sciences
School of Medical Sciences, Universiti Sains Malaysia
ISSN: 1394-195X
Vol. 25, No. 3, 2018, pp. 7-16
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Bioline Code: mj18030
Full paper language: English
Document type: Review Article
Document available free of charge
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Malaysian Journal of Medical Sciences, Vol. 25, No. 3, 2018, pp. 7-16
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Metabolic Interplay between Tumour Cells and Cancer-Associated Fibroblasts (CAFs) under Hypoxia versus Normoxia
Wanandi, Septelia Inawati; Ningsih, Sri Suciati; Asikin, Hijrah; Hosea, Rendy & Neolaka, Gladies Mercya Grameinie
Abstract
The growth of tumour cells is closely related to cancer-associated fibroblasts (CAFs)
present within their microenvironment. CAFs, the most abundant cells in tumour stroma, secrete
growth factors that play pivotal roles in tumour cell proliferation, metabolism, angiogenesis and
metastasis. Tumour cells adapt to rapid environmental changes from normoxia to hypoxia through
metabolic interplay with CAFs. In this mini review, we discuss the role of lactate dehydrogenases
(LDHs) and monocarboxylate transporters (MCTs) on the metabolic interplay between tumour
cells and CAFs under hypoxia compared to normoxia. The LDHs catalyse the interchange of
lactate and pyruvate, whereas MCTs facilitate the influx and efflux of monocarboxylates, especially
lactate and pyruvate. To sum up, tumour cells switch their metabolic state between glycolysis and
oxidative phosphorylation through metabolic interplay with CAFs, which exhibit the Warburg
effect under hypoxia and reverse Warburg effect under normoxia.
Keywords
cancer-associated fibroblasts; hypoxia; lactate dehydrogenases; monocarboxylate transporters; Warburg effect; reverse Warburg effect
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© Copyright 2018 - Penerbit Universiti Sains Malaysia Alternative site location: http://www.medic.usm.my/publication/mjms/
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