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Metabolomics Profiling on Different Stages of Colorectal Cancer: A Systematic Review
Hazwani, Mohd Yusof; Sharaniza, Ab-Rahim; Leny Suzana, Suddin; Mohd Shahril, Ahmad Saman & Musalmah, Mazlan
Abstract
Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths worldwide.
Early diagnosis and accurate staging of the disease is vital to improve the prognosis. Metabolomics
has been used to identify changes in metabolite profiles in the different stages of cancer in order
to introduce new non-invasive molecular tools for staging. In this systematic review, we aim to
identify the common metabolite changes in human biological samples and the dominant metabolic
pathways associated with CRC progression. A broad systematic search was carried out from
selected databases. Four reviewers screened and reviewed the titles, abstracts, and full-text articles
according to the inclusion and exclusion criteria. Quality assessment was conducted on the eight
articles which met the criteria. Data showed that the metabolites involved with redox status, energy
metabolism and intermediates of amino acids, choline and nucleotides metabolism were the
most affected during CRC progression. However, there were differences in the levels of individual
metabolites detected between the studies, and this might be due to the study population, sample
preparation, analytical platforms used and statistical tools. In conclusion, this systematic review
highlights the changes in metabolites from early to late stages of CRC. Moreover, biomarkers for
prognosis are important to reduce CRC-related mortality.
Keywords
colorectal cancer; metabolomics; progression; staging; biomarkers
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