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Malaysian Journal of Medical Sciences
School of Medical Sciences, Universiti Sains Malaysia
ISSN: 1394-195X
Vol. 25, No. 5, 2018, pp. 48-58
Bioline Code: mj18061
Full paper language: English
Document type: Research Article
Document available free of charge

Malaysian Journal of Medical Sciences, Vol. 25, No. 5, 2018, pp. 48-58

 en Protective Effects of N-Acetyl-L-Cysteine on the Density of Spiral Ganglion Cells and Histological Changes Induced by Continuous Noise Exposure in Rats
Hashemi Habybabady, Raheleh; Mortazavi, Seyed Bagher; Khavanin, Ali; Mirzaei, Ramazan; Arab, Mohammad Reza; Mesbahzadeh, Behzad; Hoseini, Mehran & Mohammadi, Mahdi

Abstract

    Background: Noise exposure causes loss of cochlea hair cells, leading to permanent sensorineural hearing loss, and initiates pathological changes to the bipolar primary auditory neurons (ANs). This study focuses on the effects of N-acetyl-l-cysteine (NAC) in protecting the density of spiral ganglion cells and in histological changes induced by continuous noise exposure in rats.
    Methods: Twenty-four male Wistar rats were randomly allocated into four experimental groups to receive NAC, saline, noise, or both noise and NAC. Noise exposure continued for ten days. Saline and NAC were injected daily during the noise exposure, and 2 days before and after the noise exposure. Evaluation of cochlear histopathology and the density of spiral ganglion cells was performed 21 days after exposure.
    Results: In the animals exposed to noise, a reduction in the density of spiral ganglion cells was evident in both the basal and middle turns of the cochlea. This improved on receiving NAC treatment (P = 0.046). In the histopathology evaluation, some histological changes, such as disorganised architecture of the outer hair and supporting cells and a slightly thickened basilar membrane, were found in the basal turns in the noise group.
    Conclusion: NAC offered partial protection against noise exposure by improving the density of spiral ganglion cells and reducing morphological changes.

Keywords
N-acetyl-l-cysteine; noise; cochlea; histology; spiral ganglion cells; hearing loss

 
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