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Malaysian Journal of Medical Sciences
School of Medical Sciences, Universiti Sains Malaysia
ISSN: 1394-195X
Vol. 25, No. 5, 2018, pp. 68-78
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Bioline Code: mj18063
Full paper language: English
Document type: Research Article
Document available free of charge
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Malaysian Journal of Medical Sciences, Vol. 25, No. 5, 2018, pp. 68-78
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Characterisation of the Corticospinal Tract Using Diffusion Magnetic Resonance Imaging in Unilateral and Bilateral Cerebral Palsy Patients
Samsir, Safwan; Zakaria, Rahimah; Abdul Razak, Salmi; Ismail, Mohamed Saat; Abdul Rahim, Mohd Zulkifli; Lin, Chia-Shu; Nik Osman, Nik Mohammad Faez; Asri, Mohammad Afiq & Ahmad, Asma Hayati
Abstract
Background: Neuroimaging is increasingly used to locate the lesion that causes cerebral
palsy (CP) and its extent in the brains of CP patients. Conventional structural magnetic resonance
imaging (MRI) does not indicate the connectional pattern of white matter; however, with the help
of diffusion MRI, fibre tracking of white matter can be done.
Methods: We used diffusion MRI and probabilistic tractography to identify the putative
white matter connectivity in the brains of 10 CP patients. We tracked the corticospinal tract (CST)
of the patients’ upper and lower limbs and calculated the white matter connectivity, as indexed by
streamlines representing the probability of connection of the CST.
Results: Our results show that diffusion MRI with probabilistic tractography, while having
some relation with the clinical diagnosis of CP, reveals a high degree of individual variation in the
streamlines representing the CST for upper and lower limbs.
Conclusion: Diffusion MRI with probabilistic tractography provides the state of
connectivity from lesioned areas to other parts of the brain and is potentially beneficial to be
used as an adjunct to the clinical management of CP, providing a means to monitor intervention
outcomes.
Keywords
cerebral palsy; diffusion MRI; probabilistic tractography
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© Copyright 2018 - Penerbit Universiti Sains Malaysia Alternative site location: http://www.medic.usm.my/publication/mjms/
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