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Malaysian Journal of Medical Sciences
School of Medical Sciences, Universiti Sains Malaysia
ISSN: 1394-195X
Vol. 25, No. 5, 2018, pp. 103-114
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Bioline Code: mj18066
Full paper language: English
Document type: Research Article
Document available free of charge
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Malaysian Journal of Medical Sciences, Vol. 25, No. 5, 2018, pp. 103-114
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Evaluation of Adverse Reactions Induced by Anti-Tuberculosis Drugs in Hospital Pulau Pinang
Cheah, Meng Fei; Zainal, Hadzliana & Hyder Ali, Irfhan Ali
Abstract
Background: The use of multi-drug regimens in tuberculosis (TB) treatment has been
associated with undesirable adverse drug reactions (ADRs). This study aims to assess the incidence
and impact of ADRs on TB treatment in Hospital Pulau Pinang.
Methods: This cross-sectional study was conducted via retrospective review of outpatients’
medical records. Details regarding ADRs were identified by a pharmacist and verified by a
consultant respiratory physician.
Results: A total of 91 cases, out of 210 patients enrolled in this study, were detected with
75 patients (35.7%) experienced at least one ADR. The three most common ADRs detected were
cutaneous adverse drug reactions (CADRs) (21.0%), drug-induced hepatitis (DIH) (7.1%) and
gastrointestinal disturbance (4.8%). Pyrazinamide was the most common causative agent and
15.7% of all TB patients required treatment modification due to ADRs. Females were shown to have
a higher tendency to develop ADRs than the males in this study (P = 0.009). The development of
ADRs was shown not to affect the TB treatment outcomes (P = 0.955).
Conclusion: The incidence of ADRs in this study was high so it is important to identify the
risk factors for ADRs and the individuals who have those risk factors when initiating anti-TB drugs.
These individuals require special attention when anti-TB drugs are initiated.
Keywords
adverse drug reactions; anti-tuberculosis drugs; incidence; relationship; treatment outcomes
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