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Malaysian Journal of Medical Sciences
School of Medical Sciences, Universiti Sains Malaysia
ISSN: 1394-195X
Vol. 26, No. 1, 2019, pp. 44-57
Bioline Code: mj19004
Full paper language: English
Document type: Research Article
Document available free of charge

Malaysian Journal of Medical Sciences, Vol. 26, No. 1, 2019, pp. 44-57

 en Ameliorative Effects of Aquilaria malaccensis check for this species in other resources Leaves Aqueous Extract on Reproductive Toxicity Induced by Cyclophosphamide in Male Rats
Abdul Razak, Redzuan Nul Hakim; Ismail, Faridah; Md Isa, Muhammad Lokman; Abdul Wahab, Azantee Yazmie; Muhammad, Hussin; Ramli, Roszaman & Raja Ismail, Raja Arif Shah

Abstract

Background: Cyclophosphamide (CP) is a widely used anti-neoplastic and immunosuppressive agent that is associated with adverse side effects including reproductive toxicity. Aquilaria malaccensis (AM) is a traditional medicinal plant which was reported to exhibit high anti-oxidant and free radical scavenging properties. The present study was aimed to evaluate the protective effects of AM leaves extract on sperm quality following toxic exposure to CP.
Methods: Forty-eight male Sprague Dawley rats were allocated into eight groups of six rats (n = 6): control, CP only (200 mg kg−1), AM only (100 mg kg−1, 300 mg kg−1 and 500 mg kg−1) and CP + AM (100 mg kg−1, 300 mg kg−1 and 500 mg kg−1). Animals were sacrificed after 63 days of treatment and the sperm from the caudal epididymis was taken for sperm analysis.
Results: The body and the reproductive organs weight, sperm count and motility did not differ between CP and other groups (P > 0.05). A significant increase (P < 0.05) in percentage of the dead and abnormal sperm were seen in the CP alone treated group compared to the control group. Co-administration of AM to the CP exposed rats significantly reduced the (P < 0.05) percentage of abnormal sperm as compared to the CP only group.
Conclusion: Overall, the present results represent the potential of AM to protect against CP induced reproductive toxicity.

Keywords
antioxidants; Aquilaria malaccensis; cyclophosphamide; oxidative stress; reproductive toxicity

 
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