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Malaysian Journal of Medical Sciences
School of Medical Sciences, Universiti Sains Malaysia
ISSN: 1394-195X
Vol. 26, No. 1, 2019, pp. 107-114
Bioline Code: mj19010
Full paper language: English
Document type: Research Article
Document available free of charge

Malaysian Journal of Medical Sciences, Vol. 26, No. 1, 2019, pp. 107-114

 en The Significant Association between Polymicrobial Diabetic Foot Infection and Its Severity and Outcomes
Sharifah Aisyah, Syed Hitam; Siti Asma, Hassan & Nurahan, Maning


Background: Foot infection is a major complication of diabetes mellitus (DM) and its agents are usually polymicrobial. This study aims to describe the agent and determine the association between polymicrobial infections and the severity of diabetic foot infections (DFI) and their outcomes.
Methods: This retrospective cohort study was conducted during one year and it involved 104 patients. Their records were reviewed and assessed. The causative agents and its sensitivity pattern were noted. The results were presented as descriptive statistic and analysed.
Results: A total of 133 microorganisms were isolated with 1.28 microorganisms per lesion. The microorganism isolated were 62% (n = 83) GN (Gram-negative) and 38% (n = 50) GP (Gram-positive). GN microorganisms include Pseudomonas check for this species in other resources spp (28%), Proteus check for this species in other resources spp (11%), Klebsiella check for this species in other resources spp (8%) and E. coli check for this species in other resources (4%). Staphylococcus aureus check for this species in other resources (54%) was predominant among GP, followed by Group B Streptococci (26%) and Enterococcus check for this species in other resources spp (6%). Thirty patients (28.8%) had polymicrobial infections. The association between the quantity of microorganisms and severity of DFI was significant. Among severe DFI cases, 77.8% with polymicrobial microorganisms underwent amputation compared to 33.3% with monomicrobial infection.
Conclusion: GN microorganisms were predominantly isolated from DFIs and remained sensitive to widely used agents. Polymicrobial infections were associated with DFI severity.

diabetic foot infection; diabetes mellitus; microorganisms; polymicrobial infection; severity of infection

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