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Malaysian Journal of Medical Sciences
School of Medical Sciences, Universiti Sains Malaysia
ISSN: 1394-195X
Vol. 26, No. 2, 2019, pp. 8-17
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Bioline Code: mj19017
Full paper language: English
Document type: Review Article
Document available free of charge
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Malaysian Journal of Medical Sciences, Vol. 26, No. 2, 2019, pp. 8-17
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Dietary Carbohydrate Promotes Cell Survival in Cancer Via the Up-Regulation of Fat Mass and Obesity-Associated Gene Expression Level
Doaei, Saeid; Gholamalizadeh, Maryam; Akbari, Mohammad Esmaeil; Akbari, Shayan; Feradova, Hyuliya; Rahimzadeh, Ghazaleh & Mosavi Jarrahi, Alireza
Abstract
Cancer cells are mainly dependent on glycolysis for their growth and survival. Dietary
carbohydrates play a critical role in the growth and proliferation of cancer and a low-carbohydrate
diet may help slow down the growth of tumours. However, the exact mechanisms behind this effect
are unclear. This review study aimed to investigate the effect of fat mass and obesity-associated
(FTO) gene in the association between dietary carbohydrates and cancer. This study was carried
out using keywords such as polymorphism and/or cancer and/or dietary carbohydrate and/or FTO
gene. PubMed and Science Direct databases were used to collect all related articles published from
1990 to 2018.
Recent studies showed that the level of FTO gene expression in cancer cells is dramatically
increased and may play a role in the growth of these cells through the regulation of the cellular
metabolic pathways, including the phosphoinositide 3-kinases/protein kinaseB (PI3K/AKT)
signaling pathway. Dietary carbohydrate may influence the FTO gene expression by eliminating the
inhibitory effect of adenosine monophosphate-activated protein kinase (AMPK) on the FTO gene
expression. This review summarised what has been recently discovered about the effects of dietary
carbohydrate on cancer cells and tried to determine the mediating role of the FTO gene in these
effects.
Keywords
cancer; FTO gene; dietary carbohydrate
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© Copyright 2019 - Penerbit Universiti Sains Malaysia Alternative site location: http://www.medic.usm.my/publication/mjms/
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