Malawi Medical Journal
College of Medicine, University of Malawi and Medical Association of Malawi
Vol. 20, No. 2, 2008, pp. 37-41
Bioline Code: mm08014
Full paper language: English
Document type: Research Article
Document available free of charge
Malawi Medical Journal, Vol. 20, No. 2, 2008, pp. 37-41
© Malawi Medical Journal
Why do individuals agree to enrol in clinical trials? A qualitative study of health research participation in Blantyre, Malawi|
Mfutso-Bengo, Joseph; Ndebele, Paul; Jumbe, Vincent; Mkunthi, Matilda; Masiye, Francis; Molyneux, Sassy & Molyneux, Malcolm
Current literature suggests that therapeutic misconception – a belief by participants in a clinical trial that they are in fact simply being given clinical care – is common, especially among illiterate populations in developing countries. Therapeutic misconception reflects problems in informed consent, as people agree to participate in clinical trials without being aware that the trial procedures and test products may not in fact benefit them.
In this study of Malawian adults who had participated in research projects of various kinds during the preceding years, we found that the majority participated in research for the sake of obtaining better quality treatment made available through the clinical trials as ancillary care. Their consent to participate was not due to a belief that the actual procedures of the trial would directly benefit their health. Respondents indicated that, government hospitals being crowded and commonly lacking drugs, they agreed to take part in research projects in the hope of obtaining access to ancillary care provided by clinical trials.
We conclude that in this environment, possibly owing to inadequacy of routine health services, people make rational decisions to participate in research. We question whether the term 'therapeutic misconception' accurately describes participants' motivation under conditions of limited resources. We also discuss the relevance of these findings for understanding undue inducement in clinical trials.
Alternative site location: http://revista.uft.edu.br/index.php/jbb/index