Malawi Medical Journal
College of Medicine, University of Malawi and Medical Association of Malawi
Vol. 26, No. 3, 2014, pp. 97-99
Bioline Code: mm14020
Full paper language: English
Document type: Case Report
Document available free of charge
Malawi Medical Journal, Vol. 26, No. 3, 2014, pp. 97-99
© Copyright 2014 - Malawi Medical Journal
Neoadjuvant chemotherapy in Albinos with locally advanced skin cancer at a Blantyre Hospital: - Case Series|
Chidothe, I. A. & Masamba, L.
Albinism in Africa remains a public health concern with increasing
numbers of advanced skin cancer in this population at presentation.
There are challenges with availability of Radiotherapy (RT) units in Africa
which is an important modality for controlling loco-regional disease
alone or in combination with surgery. Proposed chemotherapy regimens
have not been well validated through Randomized Controlled Trials thus
posing difficulties for standard of care for units that do not have access to
functional RT facilities. Malawi is one such country without radiotherapy.
Seven patients with locally advanced skin cancer were seen in the adult
oncology unit at Queen Elizabeth Central Hospital in Blantyre (QECH),
Malawi between 2010 and 2013. QECH is one of the teaching hospitals
in the country. All were subjected to neo-adjuvant chemotherapy. The
primary treatment aim was cyto-reduction followed by surgery whilst the
secondary outcome was general symptom control. Three patients achieved
complete responses of which two underwent resection and a pectoralis
major myocutaneous flap. One had a near complete response and three
showed partial responses.
Neo-adjuvant chemotherapy may be a possible.
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